eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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vol. 10

Diabetes mellitus and the risk of cholangiocarcinoma: an updated meta-analysis

Junshan Li, Tianjie Han, Linlin Xu, Xiaotian Luan

Prz Gastroenterol 2015; 10 (2): 108–117
Online publish date: 2015/02/10
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Introduction: A number of studies have shown that diabetes mellitus is implicated in susceptibility to several cancers. However, the relationship between diabetes and cholangiocarcinoma remain unclear.

Aim: To quantitatively assess the relationship between diabetes and incidence of cholangiocarcinoma in cohort and case-control studies.

Material and methods: A literature search was performed for entries from 1996 to 2014 using the PubMed and EMBASE databases. Studies were included if they reported odds ratios (OR) and corresponding 95% CI of cholangiocarcinoma with respect to diabetes mellitus.

Results: Twenty studies met the inclusion criteria, which included fifteen case-control studies and five cohort studies from Asia (n = 11), the United States (n = 5), and Europe (n = 4). Compared with individuals without diabetes, the pooled OR of cholangiocarcinoma was 1.74 (95% CI: 1.62–1.87, p = 0.568 for heterogeneity) for patients with diabetes, ICC (summary RR, 1.93;

95% CI: 1.65–2.25; p = 0.037 for heterogeneity), and ECC (summary RR, 1.66; 95% CI: 1.39–1.98; p = 0.001 for heterogeneity). The funnel plot revealed no evidence for publication bias concerning diabetes and the risk of CC (including ICC and ECC).

Conclusions: The findings from this meta-analysis suggest that diabetes may increase the risk of cholangiocarcinoma. This relationship needs to be confirmed by further follow-up studies.

cholangiocarcinoma, diabetes mellitus, meta-analysis


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