Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era

Estera Banasik; Agnieszka Dobrowolska; Barbara Kołodziejczak; Piotr Eder

doi:10.5114/pg.2023.133479

Abstract

4/2023 vol. 18

Original paper

Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era

Estera Banasik ¹

,

Agnieszka Dobrowolska ¹

,

Barbara Kołodziejczak ²

,

Piotr Eder ¹

Department of Gastroenterology, Dietetics, and Internal Medicine, Poznan University of Medical Sciences, University Clinical Hospital, Poznan, Poland
Faculty of Mathematics and Computer Science, Adam Mickiewicz University, Poznan, Poland

Gastroenterology Rev 2023; 18 (4): 409–415

DOI: https://doi.org/10.5114/pg.2023.133479

Online publish date: 2023/12/08

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AMA

Banasik E, Dobrowolska A, Kołodziejczak B, Eder P. Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era. Gastroenterology Review/Przegląd Gastroenterologiczny. 2023;18(4):409-415. doi:10.5114/pg.2023.133479.

APA

Banasik, E., Dobrowolska, A., Kołodziejczak, B., & Eder, P. (2023). Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era. Gastroenterology Review/Przegląd Gastroenterologiczny, 18(4), 409-415. https://doi.org/10.5114/pg.2023.133479

Chicago

Banasik, Estera, Agnieszka Dobrowolska, Barbara Kołodziejczak, and Piotr Eder. 2023. "Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era". Gastroenterology Review/Przegląd Gastroenterologiczny 18 (4): 409-415. doi:10.5114/pg.2023.133479.

Harvard

Banasik, E., Dobrowolska, A., Kołodziejczak, B., and Eder, P. (2023). Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era. Gastroenterology Review/Przegląd Gastroenterologiczny, 18(4), pp.409-415. https://doi.org/10.5114/pg.2023.133479

MLA

Banasik, Estera et al. "Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era." Gastroenterology Review/Przegląd Gastroenterologiczny, vol. 18, no. 4, 2023, pp. 409-415. doi:10.5114/pg.2023.133479.

Vancouver

Banasik E, Dobrowolska A, Kołodziejczak B, Eder P. Inflammatory bowel diseases and the clinical course of coronavirus disease 2019 – a Polish single-centre experience from the pre-vaccine era. Gastroenterology Review/Przegląd Gastroenterologiczny. 2023;18(4):409-415. doi:10.5114/pg.2023.133479.

Introduction

The data on the relationship between inflammatory bowel diseases (IBD) and the course of COVID-19 from East-Central Europe are scarce.

Aim

To assess the frequency of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in IBD patients and the impact of IBD on the COVID-19 course from the perspective of a Polish tertiary centre.

Material and methods

Data on SARS-CoV-2 infection were retrospectively collected among IBD patients hospitalized in a Polish tertiary centre from March 2020 to May 2021. A questionnaire was used assessing the IBD characteristics, other comorbidities, and the course of COVID-19.

Results

Among 350 patients, SARS-CoV-2 infection was diagnosed in 32 (9%). Severe COVID-19, defined as the need for hospitalization, was reported in 6 (19%) and mild in 26 (81%) cases. Compared to the mild COVID-19 course, patients with a severe course more often showed a higher IBD activity (3 points [IQR 2.25–3] vs. 1 point [IQR 0–2] in a semi-quantitative scale, p = 0.002), more often received steroids (67% vs. 11%, p = 0.02), and were not treated with biologics (0% vs. 46%, p = 0.07). There was a correlation between the duration of symptomatic infection and the number of comorbidities (r = 0.4, p = 0.04). No death or short-term COVID-19 complications were reported. In 25% of cases, SARS-CoV-2 infection caused new gastrointestinal symptoms.

Conclusions

IBD is not a risk factor for SARS-CoV-2 infection. Steroids and higher IBD clinical activity may increase the risk of severe COVID-19. The prognosis for COVID-19 in our cohort was good. SARS-CoV-2 infection was a common cause of gastrointestinal symptoms.