Gastroenterology Review
eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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Original paper

One-year single-center follow-up study of ustekinumab and vedolizumab use in inflammatory bowel disease Egyptian patients as second-line therapy after anti-TNF failure

Shimaa Kamel
1
,
Waleed Hamed Abd Alaty
1
,
Heba Rashad
1
,
Dina Fathy
1
,
Mohamed Abdel-Samiee
2
,
Ibrahim Hindy
1
,
Ahmed Shaban
2
,
Safaa Askar
1

  1. Tropical Medicine Department, Faculty of Medicine, Ain Shams University, Abbasiya Square, Cairo, Egypt
  2. Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt
Gastroenterology Rev
Online publish date: 2025/11/27
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1. Torres J, Mehandru S, Colombel JF, Peyrin-Biroulet L. Crohn’s disease. Lancet 2017; 389: 1741-55.
2. Ungaro R, Mehandru S, Allen PB, et al. Ulcerative colitis. Lancet 2017; 389: 1756-70.
3. Colombel JF, Narula N, Peyrin-Biroulet L. Management strategies to improve outcomes of patients with inflammatory bowel diseases. Gastroenterology 2017; 152: 351-61.e355.
4. Gionchetti P, Dignass A, Danese S, et al. 3rd European Evidence-based Consensus on the diagnosis and management of Crohn’s disease 2016: Part 2: surgical management and special situations. J Crohns Colitis 2017; 11: 135-49.
5. Sochal M, Krzywdzińska M, Gabryelska A, et al. A simple index to predict the efficiency of adalimumab treatment in Crohn disease with a limited duration of therapy. Pol Arch Intern Med 2020; 130: 910-2.
6. Stidham RW, Lee TC, Higgins PD, et al. Systematic review with network meta-analysis: the efficacy of anti-TNF agents for the treatment of Crohn’s disease. Aliment Pharmacol Ther 2014; 39: 1349-62.
7. Khanna R, Sattin BD, Afif W, et al. Review article: a clinician’s guide for therapeutic drug monitoring of infliximab in inflammatory bowel disease. Aliment Pharmacol Ther 2013; 38: 447-59.
8. Gisbert JP, Marín AC, McNicholl AG, Chaparro M. Systematic review with meta-analysis: the efficacy of a second anti-TNF in patients with inflammatory bowel disease whose previous anti-TNF treatment has failed. Aliment Pharmacol Ther 2015; 41: 613-23.
9. Gisbert JP, Chaparro M. Predictors of primary response to biologic treatment [anti-TNF, vedolizumab, and ustekinumab] in patients with inflammatory bowel disease: from basic science to clinical practice. J Crohns Colitis 2020; 14: 694-709.
10. Atreya R, Neurath MF, Siegmund B. Personalizing treatment in IBD: hype or reality in 2020? Can we predict response to Anti-TNF? Front Med 2020; 7: 517.
11. Gisbert JP, Chaparro M. Ustekinumab to treat Crohn’s disease. Gastroenterol Hepatol 2017; 40: 688-98.
12. Sandborn WJ, Feagan BG, Rutgeerts P, et al. Vedolizumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med 2013; 369: 711-21.
13. Feagan BG, Sandborn WJ, Gasink C, et al. Ustekinumab as induction and maintenance therapy for Crohn’s disease. N Engl J Med 2016; 375: 1946-60.
14. Lee SH, Kwon JE, Cho ML. Immunological pathogenesis of inflammatory bowel disease. Intest Res 2018; 16: 26-42.
15. Mosli MH, MacDonald JK, Bickston SJ, et al. Vedolizumab for induction and maintenance of remission in ulcerative colitis: a Cochrane systematic review and meta-analysis. Inflamm Bowel Dis 2015; 21: 1151-9.
16. Feagan BG, Greenberg GR, Wild G, et al. Treatment of active Crohn’s disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol 2008; 6: 1370-7.
17. Barré A, Colombel JF, Ungaro R. Review article: predictors of response to vedolizumab and ustekinumab in inflammatory bowel disease. Aliment Pharmacol Ther 2018; 47: 896-905.
18. Engel T, Yung DE, Ma C, et al. Effectiveness and safety of ustekinumab for Crohn’s disease; systematic review and pooled analysis of real-world evidence. Dig Liver Dis 2019; 51: 1232-40.
19. Rayer C, Nachury M, Bourreille A, et al. Efficacy of ustekinumab, vedolizumab, or a second anti-TNF agent after the failure of a first anti-TNF agent in patients with Crohn’s disease: a multicentre retrospective study. BMC Gastroenterol 2022; 22: 498.
20. D’Haens G, Sandborn WJ, Feagan BG, et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 2007; 132: 763-86.
21. Freeman HJ. Colorectal cancer risk in Crohn’s disease. World J Gastroenterol 2008; 14: 1810-1.
22. Ali El-Nady M, El-Hefny N, Fathy H, et al. The role of intestinal ultrasound with colour Doppler in predicting the response to biologic therapy in inflammatory bowel disease patients. Gastroenterol Rev 2024; 19: 416-22.
23. Kamel S, Sakr M, Hamed W, et al. Comparative study between bowel ultrasound and magnetic resonance enterography among Egyptian inflammatory bowel disease patients. World J Gastroenterol 2020; 26: 5884-95.
24. Askar SR, Amin A, Hagag RS, et al. Outcome of ulcerative colitis patients after one year of biological therapy in selected Egyptian patients. J Egypt Soc Parasitol 2022; 52: 279-86.
25. Townsend T, Razanskaite V, Dodd S, et al. Comparative effectiveness of ustekinumab or vedolizumab after one year in 130 patients with anti-TNF-refractory Crohn’s disease. Aliment Pharmacol Ther 2020; 52: 1341-52.
26. Rayer C, Nachury M, Bourreille A, et al. Correction: Efficacy of ustekinumab, vedolizumab, or a second anti-TNF agent after the failure of a first anti-TNF agent in patients with Crohn’s disease: a multicentre retrospective study. BMC Gastroenterol 2023; 23: 31.
27. Ollech JE, Dwadasi S, Rai V, et al. Efficacy and safety of induction therapy with calcineurin inhibitors followed by vedolizumab maintenance in 71 patients with severe steroid-refractory ulcerative colitis. Aliment Pharmacol Ther 2020; 51: 637-43.
28. Biemans VBC, van der Woude CJ, Dijkstra G, et al. Ustekinumab is associated with superior effectiveness outcomes compared to vedolizumab in Crohn’s disease patients with prior failure to anti-TNF treatment. Aliment Pharmacol Ther 2020; 52: 123-34.
29. Hyun HK, Zhang HS, Yu J, et al. Comparative effectiveness of second-line biological therapies for ulcerative colitis and Crohn’s disease in patients with prior failure of anti-tumour necrosis factor treatment. BMC Gastroenterol 2022; 22: 143.
30. Alric H, Amiot A, Kirchgesner J, et al. DOP80 Effectiveness of ustekinumab and vedolizumab in patients with Crohn’s disease refractory to anti-tumour necrosis factor: a multi-centre comparative study. J Crohn’s Colitis 2020; 14: S118-20.
31. Biemans V, van der Woude C, van der Meulen- de Jong A, et al. DOP052 Vedolizumab vs. ustekinumab for Crohn’s disease: comparative effectiveness in a real-life observational cohort study (ICC case series). J Crohn’s Colitis 2018; 12: S066-7.
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