Colorectal cancer is the most common cancer diagnosed throughout the world, especially in developed countries. Various complications and major risks are reported when performing a surgical procedure for colorectal cancer. In this background, numerous scoring systems have been developed to forecast morbidity and mortality from colorectal surgery (CRS). These scoring systems play an important role not only in patient outcomes after the completion of the surgical procedure, but also in validating the clinical practices. The current study evaluated different disease risk scoring systems, such as ACPGBI, CR-POSSUM POSSUM, American College of Surgeons National Surgery Quality Improvement Program (ACS NSQIP), AFC, and P-POSSUM, in order to scrutinize the best scoring system that can accurately predict morbidity, mortality, and 30-day mortality rates in CRS.