Ta strona używa pliki cookies, w celu polepszenia użyteczności i funkcjonalności oraz w celach statystycznych. Dowiedz się więcej w Polityce prywatności.
Korzystając ze strony wyrażasz zgodę na używanie plików cookies, zgodnie z aktualnymi ustawieniami przeglądarki.
Akceptuję wykorzystanie plików cookies
Gastroenterology Review
eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
Current issue Archive Manuscripts accepted About the journal Editorial board Reviewers Abstracting and indexing Subscription Contact Instructions for authors Publication charge Ethical standards and procedures
Editorial System
Submit your Manuscript
SCImago Journal & Country Rank
Share:
Share:
Systematic review/Meta-analysis

The effect of SARS-CoV-2 infection on the liver function tests: a systematic review and meta-analysis of observational studies

Katarzyna Kotfis
1
,
Piotr Szredzki
2
,
Dominika Maciejewska-Markiewicz
3
,
Joanna Sołek-Pastuszka
4
,
Hanna Wiśniewska
5
,
Luis F. Lara
6
,
Maria Marlicz
7
,
Mariusz Kaczmarczyk
7
,
Michał Kukla
8
,
Anna Belina
2
,
George Koulaouzidis
7
,
Marta Syczewska
5
,
Karolina Jakubczyk
3
,
Natalia Ekstedt
7
,
Ewa Stachowska
3
,
Magdalena Kaniewska
9
,
Grażyna Rydzewska
9, 10
,
Igor Łoniewski
7
,
Anastasios Koulaouzidis
11, 12
,
Wojciech Marlicz
13
,
Karolina Skonieczna-Żydecka
7

  1. Department of Anesthesiology, Intensive Care and Pain Management, Pomeranian Medical University, Szczecin, Poland
  2. Department of Surgery, Endoscopy Unit, University of Rzeszow, Poland
  3. Department of Human Nutrition and Metabolomics, Pomeranian Medical University, szczecin, Poland
  4. Department of Anesthesiology and Intensive Therapy, Pomeranian Medical University, Szczecin, Poland
  5. Department of Infectious Diseases, Hepatology and Liver Transplantation, Pomeranian Medical University, Szczecin, Poland
  6. Division of Digestive Diseases, College of Medicine, University of Cincinnati, OH, USA
  7. Department of Biochemical Science, Pomeranian Medical University, Szczecin, Poland
  8. Department of Internal Diseases and Gerontology, Collegium Medicum, Jagiellonian University, Krakow, Poland
  9. Department of Internal Diseases and Gastroenterology with Subdivision for the Treatment of Non-Specific Inflammatory Bowel Diseases, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland
  10. Collegium Medicum, Jan Kochanowski University, Kielce, Poland
  11. Department of Clinical Research, University of Southern Denmark, Odense, Denmark
  12. Research Unit of Surgery (Svendborg), Odense University Hospital, Odense, Denmark
  13. Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland
Gastroenterology Rev
Online publish date: 2025/03/27
Get citation
 
PlumX metrics:
 
1. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected [Internet]. 20 December 2023. Available at: https://www.who.int/publications-detail-redirect/10665-332299
2. Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020; 382: 1708-20.
3. Kukla M, Skonieczna-Żydecka K, Kotfis K, et al. COVID-19, MERS and SARS with concomitant liver injury – systematic review of the existing literature. J Clin Med 2020; 9: 1420.
4. Cai Q, Huang D, Yu H, et al. COVID-19: abnormal liver function tests. J Hepatol 2020; 73: 566-74.
5. Fan H, Cai J, Tian A, et al. Comparison of liver biomarkers in 288 COVID-19 patients: a mono-centric study in the early phase of pandemic. Front Med 2021; 7: 584888.
6. Ding Z, Li G, Chen L, et al. Association of liver abnormalities with in-hospital mortality in patients with COVID-19. J Hepatol 2021; 74: 1295-302.
7. Qi F, Qian S, Zhang S, Zhang Z. Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses. Biochem Biophys Res Commun 2020; 526: 135-40.
8. Chua RL, Lukassen S, Trump S, et al. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis. Nat Biotechnol 2020; 38: 970-9.
9. Mohamed DZ, Ghoneim MES, Abu-Risha SES, et al. Gastrointestinal and hepatic diseases during the COVID-19 pandemic: manifestations, mechanism and management. World J Gastroenterol 2021; 27: 4504-35.
10. Tian D, Ye Q. Hepatic complications of COVID-19 and its treatment. J Med Virol 2020; 92: 1818-24.
11. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; 395: 497-506.
12. Yang RX, Zheng RD, Fan JG. Etiology and management of liver injury in patients with COVID-19. World J Gastroenterol 2020; 26: 4753-62.
13. Sahu T, Pande B, Pl M, Verma HK. Liver dysfunction during COVID-19 pandemic: contributing role of associated factors in disease progression and severity. World J Hepatol 2022; 14: 1099-10.
14. Wang SF, Tseng SP, Yen CH, et al. Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins. Biochem Biophys Res Commun 2014; 451: 208-14.
15. Wen J, Cheng Y, Ling R, et al. Antibody-dependent enhancement of coronavirus. Int J Infect Dis 2020; 100: 483-9.
16. Bangash MN, Patel J, Parekh D. COVID-19 and the liver: little cause for concern. Lancet Gastroenterol Hepatol 2020; 5: 529-30.
17. Saha L, Vij S, Rawat K. Liver injury induced by COVID 19 treatment – what do we know? World J Gastroenterol 2022; 28: 6314-27.
18. Montori M, Baroni GS, Santori P, et al. Liver damage and COVID-19: at least a “two-hit” story in systematic review. Curr Issues Mol Biol 2023; 45: 3035-47.
19. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021; 372: n71.
20. Ottawa Hospital Research Institute [Internet]. 20 December 2023. Available from https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
21. Sawicka B, Aslan I, Della Corte V, et al. The coronavirus global pandemic and its impacts on society. Coronavirus Drug Discov 2022; 267-311.
22. Chaudhry F, Lavandero S, Xie X, et al. Manipulation of ACE2 expression in COVID-19. Open Heart 2020; 7: e001424.
23. Iluz-Freundlich D, Zhang M, Uhanova J, Minuk GY. The relative expression of hepatocellular and cholestatic liver enzymes in adult patients with liver disease. Ann Hepatol 2020; 19: 204-8.
24. Wang Y, Liu S, Liu H, et al. SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19. J Hepatol 2020; 73: 807-16.
25. Vento S, Nobili V. Aminotransferases as predictors of mortality. Lancet 2008; 371: 1822-3.
26. Tang H, Zhou L, Li X, et al. Drug-induced liver injury associated with lopinavir-ritonavir in patients with COVID-19: a disproportionality analysis of U.S. Food and Drug Administration adverse event reporting system (FAERS) data. Int J Clin Pharm 2021; 43: 1116-22.
27. Wiśniewska H, Skonieczna-Żydecka K, Parczewski M, et al. Hepatotropic properties of SARS-CoV-2 – preliminary results of cross-sectional observational study from the first wave COVID-19 pandemic. J Clin Med 2021; 10: 672.
28. Qi RB, Wu ZH. Association between COVID-19 and chronic liver disease: mechanism, diagnosis, damage, and treatment. World J Virol 2023; 12: 22-9.
29. Deutsch-Link S, Curtis B, Singal AK. Covid-19 and alcohol associated liver disease. Dig Liver Dis 2022; 54: 1459-68.
30. Effenberger M, Grander C, Fritsche G, et al. Liver stiffness by transient elastography accompanies illness severity in COVID-19. BMJ Open Gastroenterol 2020; 7: e000445.
31. Marjot T, Moon AM, Cook JA, et al. Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study. J Hepatol 2021; 74: 567-77.
32. Guler E, Unal NG, Cinkooglu A, et al. Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans. Abdom Radiol [Internet]. 28 March 2021; Available from: http://link.springer.com/10.1007/s00261-020-02805-y
33. Uchida Y, Uemura H, Yamaba S, et al. Significance of liver dysfunction associated with decreased hepatic CT attenuation values in Japanese patients with severe COVID-19. J Gastroenterol 2020; 55: 1098-106.
Copyright: © 2025 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
Quick links
© 2025 Termedia Sp. z o.o.
Developed by Bentus.