eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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vol. 13
Review paper

The influence of antibiotics and dietary components on gut microbiota

Ruth K. Dudek-Wicher, Adam Junka, Marzenna Bartoszewicz

Gastroenterology Rev 2018; 13 (2): 85–92
Online publish date: 2018/05/25
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The gut microbiota acts as a real organ. It exerts important metabolic functions, and regulates the inflammatory response by stimulating the immune system. Gut microbial imbalance (dysbiosis) has been linked to important human diseases and inflammation-related disorders. The symbiotic interactions between resident microorganisms and the gastrointestinal tract significantly contribute to maintaining gut homeostasis. The present review summarizes our knowledge regarding the impact of different antibiotics causing such long-term consequences as decreased microbial diversity, modulation of the Bacteroidetes/Firmicutes ratio, Clostridium difficile overgrowth, and increased expansion of the opportunistic pathogens Salmonella typhimurium, Escherichia spp., and Klebsiella spp. Also, food additives, such as emulsifiers and artificial sweeteners, which are meant to reduce the risk of obesity and diabetes, may actually increase the risk of diseases due to microbial alterations. On the other hand, dietary components such as polyphenols, omega-3 acids or curcumin may positively affect gut microbiota composition.

microbiota, antibiotics, diet

Thomas S, Izard J, Walsh E, et al. The host microbiome regulates and maintains human health: a primer and perspective for non-microbiologists. Cancer Res 2017; 77: 1783-812.
Matijaši M, Meštrović T, Perić M, et al. Modulating composition and metabolic activity of the gut microbiota in IBD patients. Int J Mol Sci 2016; 17: 578.
Distrutti E, Monaldi L, Ricci P, et al. 2016 irritable bowel syndrome: global view gut microbiota role in irritable bowel syndrome: new therapeutic strategies. World J Gastroenterol 2016; 22: 2219-41.
Forsythe P, Kunze W. Voices from within: gut microbes and the CNS. Cell Mol Life Sci 2013; 70: 55-69.
Burke DG, Fouhy F, Harrison M, et al. The altered gut microbiota in adults with cystic fibrosis. BMC Microbiol 2017; 17: 58.
Kaufman D, Kelly J, Curhan G, et al. Oxalobacter formigenes may reduce the risk of calcium oxalate kidney stones. J Am Soc Nephrol 2008; 19: 1197-203.
Sela DA, Mills D. Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides. Trends Microbiol 2011; 18: 298-307.
Jandhyala S, Talukdar R, Subramanyam C, et al. Role of the normal gut microbiota. World J Gastroenterol 2015; 21: 8787-803.
Ozdal T, Sela DA, Xiao J, et al. The reciprocal interactions between polyphenols and gut microbiota and effects on bioaccessibility. Nutrients 2016; 8: 78.
Klaassen CD, Yue Cui JY. Review: mechanisms of how the intestinal microbiota alters the effects of drugs and bile acids. Drug Metab Dispos 2015; 43: 1505-21.
Spanogiannopoulos P, Bess EN, Carmody RN, et al. The microbial pharmacists within us: a metagenomic view of xenobiotic metabolism. Nat Rev Microbiol 2016; 14: 273-87.
Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J 2017; 474: 1823-36.
Bron PA, Kleerebezem M, Brummer RJ, et al. Can probiotics modulate human disease by impacting intestinal barrier function? Br J Nutr 2017; 117: 93-107.
Marlicz W, Yung DE, Skonieczna-Żydecka K, et al. From clinical uncertainties to precision medicine: the emerging role of the gut barier and microbiome in small bowel functional disease. Expert Rev Gastroenterol Hepatol 2017; 11: 961-78.
Claus SP, Guillou H, Ellero-Simatos S. The gut microbiota: a major player in the toxicity of environmental pollutants? NPJ Biofilms Microbiomes 2017; 3: 17001.
Mahana D, Trent C, Zachary D. Kurtz Z, et al. Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet. Genome Med 2016; 8: 48.
Ubeda C, Pamer EG. Antibiotics, microbiota, and immune defense. Trends Immunol 2012; 33: 459-66.
Gupta S, Allen-vercoe E, Petrof EO. Fecal microbiota transplantation: in perspective. Ther Adv Gastroenterol 2016; 9: 229-39.
Leszczyszyn JJ, Radomski M, Leszczyszyn AM. Intestinal microbiota transplant – current state of knowledge. Reumatologia 2016; 54: 24-8.
Zimmer J, Lange B, Frick JS, et al. A vegan or vegetarian diet substantially alters the human colonic faecal microbiota. Eur J Clin Nutr 2011; 66: 53-6.
Koeth RA, Wang Z, Levison BS, et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med 2013; 19: 576-85.
Bonder MJ, Tigchelaar EF, Cai X, et al. The influence of a short-term gluten-free diet on the human gut microbiome. Genome Med 2016; 8: 45.
Del Chierico F, Vernocchi P, Dallapiccola B, et al. Mediterranean diet and health: food effects on gut microbiota and disease control. Int J Mol Sci 2014; 15: 11678-99.
Panda S, El Khader I, Casellas F, et al. Short-term effect of antibiotics on human gut microbiota. PLoS One 2014; 9: e95476.
Jernberg C, Löfmark S, Edlund C, et al. Long-term impacts of antibiotic exposure on the human intestinal microbiota. Microbiology 2010; 156: 3216-23.
Schubert A, Sinani H, Schloss. PD. Antibiotic-induced alterations of the murine gut microbiota and subsequent effects on colonization resistance against Clostridium difficile. MBio 2015; 6: e00974-15.
Perez-Cobas AE, Artacho A, Knecht H, et al. Differential effects of antibiotic therapy on the structure and function of human gut microbiota. PLoS One 2013; 8: e80201.
Ng K, Ferreyra J, Higginbottom S, et al. Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens. Nature 2013; 502: 96-99.
Huang YL, Chassard C, Hausmann M, et al. Sialic acid catabolism drives intestinal inflammation and microbial dysbiosis in mice. Nat Commun 2015; 6: 8141.
Chassaing B, Koren O, Goodrich JK, et al. Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 2016; 519: 404-13.
Spencer M, Gupta A, Van Dam L, et al. Artificial sweeteners: a systematic review and primer for gastroenterologists. J Neurogastroenterol Motil 2016; 22: 168-80.
Zhang X, Zhao Y, Xu J, et al. Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats. Sci Rep 2015; 5: 14405.
McFadden R, Larmonier C, Shehab K, et al. The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflamm Bowel Dis 2015; 21: 2483-94.
Byerleya LO, Samuelson D, Blanchard E, et al. Changes in the gut microbial communities following addition of walnuts to the diet. J Nutr Biochem 2017; 48: 94-102.
Sardecka I, Krogulska A, Toporowska-Kowalska E. The influence of dietary immunomodulatory factors on development of food allergy in children. Postep Dermatol Alergol 2017; 34: 89-96.
Jacobs DM, Gaudier E, van Duynhoven J, et al. Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: a role for metabolomics. Curr Drug Metab 2009; 10: 41-54.
Cardona F, Andrés-Lacuevac C, Tulipani S, et al. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem 2013; 24: 1415-22.
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