Gastroenterology Review
eISSN: 1897-4317
ISSN: 1895-5770
Gastroenterology Review/Przegląd Gastroenterologiczny
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Original paper

The role of clinical, laboratory, and imaging findings in the diagnosis of appendicitis: a retrospective analysis

Nina Miteva
1
,
Francesk Mulita
2, 3
,
Athanasios Papatriantafyllou
4
,
Vasileios Leivaditis
4
,
Gregory Tripsianis
5
,
Savas Deftereos
6
,
Konstantinos Vafiadis
7
,
Alexandros Mitrakas
8
,
Anastasios Karayiannakis
9
,
Michail Pitiakoudis
9
,
Konstantinos Romanidis
9

  1. Emergency Department, General Hospital of Didymoteicho, Didymoteicho, Greece
  2. Department of Surgery, General Hospital of Eastern Achaia – Unit of Aigio, Aigio, Greece
  3. Department of Surgery, General University Hospital of Patras, Patras, Greece
  4. Department of Cardiothoracic and Vascular Surgery, WestpfalzKlinikum, 67655 Kaiserslautern, Germany
  5. Laboratory of Medical Statistics, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
  6. Department of Radiology, School of Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece
  7. Department of Radiology, General Hospital of Didymoteicho, Didymoteicho, Greece
  8. Department of Surgery, General Hospital of Didymoteicho, Didymoteicho, Greece
  9. Second Department of Surgery, Democritus University of Thrace, Medical School, Alexandroupolis, Greece
Gastroenterology Rev
DOI: https://doi.org/10.5114/pg.2025.156784
Online publish date: 2025/12/07
Article file
- The role of clinical.pdf  [0.11 MB]
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1. D’Souza N, Nugent K. Appendicitis. Am Fam Physician 2016; 93: 142-3.
2. Hardin DM Jr. Acute appendicitis: review and update. Am Fam Physician 1999; 60: 2027-34.
3. Lotfollahzadeh S, Lopez RA, Deppen JG. Appendicitis. [Updated 2024 Feb 12]. In: Statpearls [Internet]. Treasure Island (FL): statpearls Publishing; 2024 Jan-.
4. Lee JH, Park YS, Choi JS. The epidemiology of appendicitis and appendectomy in South Korea: national registry data. J Epidemiol 2010; 20: 97-105.
5. Sulu B, Gunerhan Y, Palanci Y, et al. Epidemiological and demographic features of appendicitis and influences of several environmental factors. Turk J Trauma Emergency Surg 2010; 16: 38-42.
6. Gomes CA, Abu-Zidan FM, Sartelli M, et al. Management of Appendicitis Globally Based on Income of Countries (MAGIC) study. World J Surg 2018; 42: 3903-10.
7. Livingston EH, Woodward WA, Sarosi GA, Haley RW. Disconnect between incidence of nonperforated and perforated appendicitis: implications for pathophysiology and management. Ann Surg 2007; 245: 886-92.
8. Di Saverio S, Podda M, De Simone B, et al. Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines. World J Emerg Surg 2020; 15: 27.
9. Greogory S, Kuntz K, Sainfort F, Kharbanda A. Cost-effectiveness of integrating a clinical decision rule and staged imaging protocol for diagnosis of appendicitis. Value Health 2016; 19: 28-35.
10. Sippola S, Virtanen J, Tammilehto V, et al. The accuracy of low-dose computed tomography protocol in patients with suspected acute appendicitis: the OPTICAP study. Ann Surg 2020; 271: 332-8.
11. Yu MC, Feng YJ, Wang W, et al. Is laparoscopic appendectomy feasible for complicated appendicitis ? A systematic review and meta-analysis. Int J Surg 2017; 40: 187-97.
12. Nakhamiyayev V, Galldin L, Chiarello M, et al. Laparoscopic appendectomy is the preferred approach for appendicitis: a retrospective review of two practice patterns. Surg Endosc 2010; 24: 859-64.
13. Humes DJ, Simpson J. Acute appendicitis. BMJ 2006; 333: 530-4.
14. Abdulmomen AA, AlZahrani AS, Al Mulla LA, et al. Acute perforated appendicitis associated with appendiceal diverticulitis in a young man: a case report with literature review. Am J Case Rep 2022; 23: e934838-1-7.
15. Nshuti R, Kruger D, Luvhengo TE. Clinical presentation of acute appendicitis in adults at the Chris Hani Baragwanath academic hospital. Int J Emergency Med 2014; 7: 12.
16. Moris D, Paulson EK, Pappas TN. Diagnosis and management of acute appendicitis in adults: a review. JAMA 2021; 326: 2299-311.
17. Chisthi MM, Surendran A, Narayanan JT. RIPASA and air scoring systems are superior to Alvarado scoring in acute appendicitis: diagnostic accuracy study. Ann Med Surg 2012; 59: 138-42.
18. Chong CF, Adi MIW, Thien A, et al. Development of the RIPASA score: a new appendicitis scoring system for the diagnosis of acute appendicitis. Singapore Med J 2010; 51: 220-5.
19. Shuaib A, Shuaib A, Fakhra Z, et al. Evaluation of modified Alvarado scoring system and RIPASA scoring system as diagnostic tools of acute appendicitis. World J Emergency Med 2017; 8: 276-80.
20. Mulita F, Plachouri K, Liolis E, et al. Comparison of intra-abdominal abscess formation after laparoscopic and open appendectomy for complicated and uncomplicated appendicitis: a retrospective study. Videosurgery Miniinv 2021; 16: 560-5.
21. Mulita F, Oikonomou N, Provatidis A, et al. Roseomonas gilardii in patient with leukemia and acute appendicitis: case report and review. Pan Afr Med J 2020; 36: 283.
22. Verras GI, Mulita F. Butyrylcholinesterase levels correlate with surgical site infection risk and severity after colorectal surgery: a prospective single-center study. Front Surg 2024; 11: 1379410.
Copyright: © 2025 Termedia Sp. z o. o. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License (http://creativecommons.org/licenses/by-nc-sa/4.0/), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
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