Transient shortening of activated 
partial thromboplastin time 
and prothrombin time associated 
with transient global amnesia

Dariusz Dziubek; Karolina Dziubek; Marcelina Stodolak

doi:10.5114/ppn.2025.149970

eISSN: 2720-5371
ISSN: 1230-2813

Advances in Psychiatry and Neurology/Postępy Psychiatrii i Neurologii

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1/2025
vol. 34

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Opis przypadku

Transient shortening of activated partial thromboplastin time and prothrombin time associated with transient global amnesia

Dariusz Dziubek

¹

,

Karolina Dziubek

²

,

Marcelina Stodolak

³

Deparment of Neurology, Holy Family Specjalistic Hospital, Rudna Mala, Poland
Dentist, private practice, Rzeszow, Poland
Collegium Medicum, University of Rzeszow, Poland

Adv Psychiatry Neurol 2025; 34 (1): 54-57

DOI: https://doi.org/10.5114/ppn.2025.149970

Data publikacji online: 2025/04/30

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Metryki PlumX:

Purpose:
Transient global amnesia (TGA) manifests as acute short-term memory disturbances lasting up to 24 hours. The pathophysiology of the disease remains unclear. This paper presents the case of a patient with recurrent TGA, in whom a shortening of coagulation times and high blood pressure peaks were observed during each acute phase of the disease, suggesting transient increased blood coagulability and transient dysregulation of autonomic blood pressure control.

Case description:
A 59-year-old patient with medical history of migraine and arterial hypertension was diagnosed with recurrent TGA (two episodes within a year). Each time, upon admission to hospital, high blood pressure peaks were recorded and activated partial thromboplastin time (aPTT) and prothrombin time (PT) were shortened with gradual normalization over the following days.

Comment:
The shortening of aPTT and PT may suggest a relationship between TGA and transient blood coagulation disorders in the acute phase.

Transient shortening of activated partial thromboplastin time and prothrombin time associated with transient global amnesia

Dariusz Dziubek 1 , Karolina Dziubek 2 , Marcelina Stodolak 3

Dariusz Dziubek

¹

,

Karolina Dziubek

²

,

Marcelina Stodolak

³