eISSN: 2083-8441
ISSN: 2081-237X
Pediatric Endocrinology Diabetes and Metabolism
Bieżący numer Archiwum Artykuły zaakceptowane O czasopiśmie Rada naukowa Recenzenci Bazy indeksacyjne Prenumerata Kontakt Zasady publikacji prac
SCImago Journal & Country Rank

1/2019
vol. 25
 
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Opis przypadku

Objawowa hiponatremia w przebiegu kwasicy ketonowej u 5-letniego dziecka z nowo rozpoznaną cukrzycą – doświadczenia własne

Anna Kącka
,
Agnieszka Banach
,
Jolanta Jabłońska
,
Dorota Charemska
,
Bożenna Klonowska
,
Barbara Głowińska-Olszewska

Pediatr Endocrinol Diabetes Metab 2019; 25 (1): 48-51
Data publikacji online: 2019/05/23
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Introduction

Hyponatremia is the one of the most common electrolyte abnormality in the clinical practice and is associated with increased morbid-ity and mortality.
Decreased serum sodium levels are occasionally observed in patients with diabetes mellitus, especially in those, who present with diabetic ketoacidosis and can be attributed to numerous underlying pathogenetic mechanisms. [1]
Diabetic ketoacidosis (DKA) results from deficiency of circulating insulin and increased levels of the counterregulatory hor-mones (catecholamines, glucagon, cortisol, growth hormone). It is characterized by severe depletion of water and electrolytes from both the intra- and extracellular fluid compartments. Frequencies range from approximately 15% to 70% in Europe and North America at the diabetes type 1 onset, while in children with established disease, is 1% to 10% per patient per year. The proper therapy can prevent de-velopment of the complications. Some of them are related to the DKA itself, while the others might be unfortunately iatrogenic. The most commonly seen are: hypoglycemia, hyperglycemia, hypokalemia, hyperkalemia, hyponatremia, hypernatremia, hypovolemic shock, acute kidney failure. Neurological complications including brain oedema, venous thrombosis and others like rhabdomyolysis, gastroin-testinal bleeding, sepsis, disseminated intravascular coagulation are less frequent [2].
Hyponatremia seen in the DKA can be differentiate based on the direct measurement of plasma osmolality (Posm) between hypotonic (with decreased Posm) and associated with normal or even increased tonicity.
In the course of DKA marked hyperglycemia leads to increased Posm frequently in the range of 300 to 350 mmol/kg and glucose, largely restricted to the extracellular space, causes osmotic movement of water into the extra- cellular space thereby causing dilution hyponatremia. Once the osmotic diuresis rises, the hypotonic hyponatremia can be noted. Moreover the excretion of β-hydroxybutyrate and acetoacetate obligate urine sodium losses resulting in aggravation of hypovolemia and decreased Posm [3].
Recent studies also revealed that the osmoregulation of arginine vasopressin (AVP) is altered and its plasma concentration is increased in DKA [4, 5].
The aim of this report is to present own experience with symptomatic hyponatremia in the new diagnosed patient with diabe-tes mellitus type 1.

Case presentation

Patient JC, male, 5.2-years-old. Born from 3rd pregnancy, in 39 Hbd, with body weight 3340 g, in good general condition (Apgar 10). In the 2nd month of life hospitalized due to pneumonia, urinary tract infection and hyponatremia, with the final diagnosis based on the urine steroid profile – pseudohypoaldosteronism. Since then no further episodes of hyponatremia has been noted. Otherwise healthy. Admitted to the Endocrinological Ward with the history of polyuria, nycturia in the past month. On physical examination – generally unwell, apathetic, but with logical contact, decreased skin turgor, dry mucous, capillary refill time 4-5 seconds, heart rate 112/min, blood pressure (BP) 112/74 mm Hg, oxygen saturation 95%. In the laboratory test hyperglycemia, compensated metabolic acidosis were pre-sent, HbA1C – 9,9%. Intravenous fluids (0,9% NaCl, followed by 5% glucose combined with 0,9% NaCl) and intravenous insulin with potassium supplementation (two hours after initial hydration) were started. Normoglycemia was achieved after 6 hours of treatment. In the next 36 hours patient started to complain about abdominal pain, vomited 3 times, no fever, normal vital signs, glucose levels maintain in the range between 156-166 mg/dl. Intravenous insulin therapy and fluids were continued. In the 42 hour from admission sudden lost of consciousness and generalized tonic – clonic seizures were observed, stopped by diazepam given per rectum. In the laboratory test – hyponatremia was detected, with decreased plasma osmolality, increased urine osmolality and increased urine sodium concentration. ACTH, cortisol level, liver function test, kidney function test, thyroid function test, lipid profile were normal. Aldosterone concertation was raised with decreased renin activity.
CT of the head didn’t reveal any abnormalities. On physical examination there were no signs of dehydration and blood pres-sure maintained stable. Treatment with 3%NaCl and hydrocortisone (HCT) intravenously was introduced, together with fluid restriction, intravenous insulin therapy maintained. After 12 hours normonatremia was established. The therapy with 3% NaCl infusion was discon-tinued and intravenous insulin was replaced by subcutaneous long-acting and rapid acting insulin. Hydrocortisone intravenously has been continued for the following 3 days – with gradual reduction of the does. Due to relapse of mild hyponatremia, he was kept on fluid restriction and oral sodium chloride (kitchen salt 3 g per day in divided portion) was given to the food for the next 4 days. In the control laboratory test after 10 days from the first presentation of the hyponatremia – Na, POsm, urinary steroid profile analysis using GC-MS, aldosterone, renin, TSH, fT4 – were normal and 21-hydroxylase antibodies were negative. Unfortunately AVP was checked for the very first time at that stage and was decreased (3,5 ng/l, N < 8). Additionally, DM1 was confirmed with positive antibodies: anti-GAD, IA2 and low C-peptide. Ultrasound of the abdomen showed no abnormalities and in ECHO – PFO was reported. Patient was discharged home in general well state on normal fluid intake without sodium chloride supplementation.
After one month he was admitted for elective MRI of the pituitary gland where no abnormalities were reported and laboratory tests including Na, K, Cl, POsm, morning cortisol were in the normal range (Tables I, II).
Currently the patient has been treated for T1DM for over a year under the Diabetology Outpatient Clinic with insulin pump and no episodes of hyponatremia were reported.

Discussion

Hyponatremia is common electrolyte abnormality encountered in children, leading in the most serious cases to hyponatremic en-cephalopathy. The clinical features are headache, nausea, vomiting, seizures, resulting from the brain oedema. Early diagnosis, differen-tial between acute vs. chronic hyponatremia and introduction the optimal treatment can prevent developing cerebral demyelination and lethal outcome [7, 8]. The presented case shows how sudden and severe might be the course of hyponatremia together with the diagnos-tic difficulties. Despite the initial normal levels of sodium, proper hydration and insulin therapy which allowed to achieve normoglyce-mia, patient developed hyponatremia. That inclined us to look for other causes than those related to diabetes mellitus. Hypothyrodism, kidney, liver and heart failure were excluded. In the differential diagnosis adrenal insufficiency, pseudohypoaldosteronism and SIADH were taken under the consideration [6]. With the patient history of transient pseudhypoaldosteronism the diagnosis was also review. Pseudohypoaldosteronism defines the state characterized by renal tubular unresponsiveness to aldosterone. Genetically caused primary (type 1 and type 2) and transient secondary forms exist. Secondary PHA is a transient aldosterone resistance condition mostly occurring in relation with urinary tract infection and/or malformations and its laboratory characteristics are similar to primary PHA. Clinical presentation includes hyponatremia, dehydration, hyperkaliemia, acidosis, increased aldosteron and renin activity. Diagnosis is con-firmed based on the urine steroid profile. Noted elevation of the aldosteron and decreased renin in the presented case, seems to be sec-ondary response to the hyponatremia, what can be supported by the fact that they went back to normal after correction of the sodium level [7].
Adrenal insufficiency might has a broad spectrum of underlying causes. In this case the most likely diagnosis were consid-ered, including congenital adrenal hyperplasia, secondary adrenal insufficiency and Addison’s disease. Normal levels of the cortisol, ACTH, the urine steroid profile and negative antibodies against adrenal cortex allowed to exclude disorders related to the disturbed pro-duction of the steroids [8].
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is defined by the hyponatremia and plasma hypoosmolal-ity (< 275 mOsm/kg H2O), UOsm above 100 mOsm/kg H2O, high urine sodium above 40 mmol/l, resulting from inappropriate, con-tinued secretion or action of the antidiuretic hormone arginine vasopressin (AVP) despite normal or increased plasma volume, which results in impaired water excretion. All of mentioned above were met in this case. Patient also respond well to the restriction of the fluids and oral supplementation of the sodium chloride [9].
No further treatment has been required and relapses has been observed [10].

Conclusions

Symptomatic hyponatremia is not a common complication seen in patients with diabetes mellitus, even during the DKA. It can de-velop at each stage of treatment, as a complication of hyperglycemia and intensity of the therapy, but also the other underlying causes should be considered and excluded. Making the proper diagnosis helps predict the clinical course and guide the most appropriate man-agement.
In presented case hyponatremia occurred for the first time during the infections (urinary tract infection and pneumonia) and for the second time after the episode of mild DKA. Despite those periods, patient maintains normal plasma sodium level and doesn’t require any treatment. Based on that, we recommended the routine control of the electrolytes levels and also during the course of the acute diseases or occurrence of the signs and symptoms of hyponatremia.

References

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