The role of major virulence factors and pathogenicity
of adherent-invasive Escherichia coli in patients with
Crohn’s disease

Khalid A. Abdelhalim; Ataç Uzel; Nalan Gülşen Ünal

doi:10.5114/pg.2020.93235

eISSN: 1897-4317
ISSN: 1895-5770

Gastroenterology Review/Przegląd Gastroenterologiczny

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4/2020
vol. 15

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abstract:

Review paper

The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease

Khalid A. Abdelhalim

¹

,

Ataç Uzel

¹

,

Nalan Gülşen Ünal

²

Basic and Industrial Microbiology Section, Department of Biology, Faculty of Science, Ege University, Izmir, Turkey

Department of Gastroenterology, Faculty of Medicine, Ege University, Izmir, Turkey

Gastroenterology Rev 2020; 15 (4): 279–288

DOI: https://doi.org/10.5114/pg.2020.93235

Online publish date: 2020/12/10

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Inflammatory bowel disease (IBD) is a term that describes Crohn’s disease (CD) and ulcerative colitis (UC), and these two conditions are characterised by chronic inflammation of the gastrointestinal tract. Dysbiosis of intestinal microbiota has been consistently linked to patients with IBD. In the last two decades, the progressive implication of adherent-invasive Escherichia coli (AIEC) pathogenesis in patients with CD has been increasing. Here we discuss recent findings that indicate the role and mechanisms of AIEC in IBD. We also highlight AIEC virulence factor genes and mechanisms that suggest an important role in the severity of inflammation in CD patients. Finally, we emphasise data on the prevalence of AIEC in CD patients.

keywords:

The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease

Khalid A. Abdelhalim 1 , Ataç Uzel 1 , Nalan Gülşen Ünal 2

adherent-invasive Escherichia coli, Escherichia coli, Crohn’s disease, inflammatory bowel disease, virulence factors

Khalid A. Abdelhalim

¹

,

Ataç Uzel

¹

,

Nalan Gülşen Ünal

²